What is hyaluronidase and what is it used for?

Hyaluronidase (also known as Vitrase) is a medication that can be used to dissolve hyaluronic acid (HA) based dermal fillers such as Restylane, Perlane, Juvederm, and more.  This product is derived from sheep or cows to create an enzyme antedote for HA based fillers.  This option is extremely useful in the event that a patient dislikes their results from Restylane, Juvederm, etc. and wants the product removed.  Unfortunately, it’s difficult to reverse only very specific portions of the product and one must be prepared to lose all of the benefits of their filler treatment when injecting hyaluronidase.  Because hyaluronidase is only effective for HA fillers, it is not useful for other cosmetic dermal fillers such as Radiesse or Sculptra.


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Although not common practice in our industry, Celibre performs an allergy test prior to the use of hyaluronidase to ensure there is no adverse patient reaction.  Although an allergic or hypersensitive reaction is uncommon, it is highly recommended to take the time to rule this out.


Lori Haney, RN, MEP-C

Certified Medical Laser Safety Officer

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Posted by administrator on Monday, January 18, 2010 12:15 PM
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