Comparison of Dermal Fillers

Are you thinking about having treatment with dermal filler? If so, we’d like to give you a brief overview of four of the very commonly used products that we love here at Celibre Medical Corporation. We believe it is important for you to understand your treatment choices and why certain products might be better for you than others. We also believe that the more knowledge and education we impart to our patients, the happier and more satisfied they are with their treatment—so let’s give you the rundown.

Dermal, Wrinkle Fillers Procedure

RestylaneThe four most commonly used dermal fillers at our practice are Restylane, Restylane Lyft, Juvederm and Radiesse. The first three are hyaluronic acid (HA) based dermal fillers and Radiesse is a product that is made from calcium hydroxyapatite (CHA).

JuvedermHyaluronic acid (HA) is a sugar-like molecule that can be found in our skin and joints. The filler products are just synthetic versions of what we naturally have in our body. So there is virtually no risk of allergic reaction to these products, but they do slowly degrade over time. What makes HA so great as a filler is that each molecule has the capability to absorb up to 1000 times its own weight in water! This means that these gels don’t just work by acting like a filler all alone, they work hard to pull in extra water around them once they’re in the skin. This makes them excellent volumizers that look soft and natural. They are also 100% reversible, which makes them extremely safe. Each varies a bit in consistency, but generally, they are all soft, pliable gels. Therefore, all are very safe and effective fillers for any area, but especially sensitive ones such as the lips and under the eyes.

RadiesseBy contrast, Radiesse is a great “foundational” dermal filler. It is much thicker than the HA gels, and the CHA particles act like little “scaffolds” that trigger your body to form its own collagen around them. It is our go-to for building up volume in larger areas, such as the cheeks or backs of the hands. Because it’s not as easily broken down by the body and it stimulates collagen remodeling, it lasts longer than the HA fillers. But it isn’t reversible, so you must make sure that your injector has a good base of knowledge and expert technique to ensure you get the results you are looking for with Radiesse. It isn’t good for the sensitive areas listed above, so beware if your injector suggests using it there!


  Restylane Restylane Lyft Juvederm Radiesse
Active Ingredient Hyaluronic Acid Hyaluronic Acid Hyaluronic Acid Calcium Microspheres
Duration of Effect

3-12 Months

Depends on Area

6-12 Months

Depends on Area

3-12 Months

Depends on Area

9-12 Months

Depends on Area

Time to Take Effect Immediate Immediate Immediate Immediate
Location to Use Under eyes, Cheeks, Temples, Laugh Lines, Chin, Lips Under eyes, Cheeks, Temples, Laugh Lines, Chin, Lips Under eyes, Cheeks, Temples, Laugh Lines, Chin, Lips Cheeks, Laugh Lines, Chin
Reversible Yes Yes Yes No
Consistency Like syrup or thick hand cream Like syrup or thick hand cream Like syrup or thick hand cream Between Toothpaste and Play-doh


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